Nuveen Inks San Diego HQ Lease Renewal

October 10, 2025

Office Brokerage News San Diego More West

A biotechnology company will continue to occupy the space.

In one of the largest life science leases in San Diego year-to-date, Invivoscribe has renewed its 52,477-square-foot U.S. headquarters commitment at 10222 Barnes Canyon Road. Newmark represented the global biotechnology company.

The firm has been a tenant at the building for nearly 10 years. Nuveen Real Estate owns the 81,976-square-foot asset, according to Yardi Matrix. The company acquired it in October 2018 from Bollert Lebeau Commercial Real Estate for $43.2 million—about $547 per square foot.

Located within the Sorrento Mesa submarket, the two-story facility is close to Interstate 805 and 15 miles from downtown San Diego. The city’s international airport is within 17 miles south.

Built in 1985, the low-rise underwent complete renovations in 2018 and was redeveloped into a life science R&D building, reflecting ongoing demand for lab space across the submarket.

The property has purpose-built laboratories, cGMP manufacturing space, conference rooms, break rooms and an outdoor patio, along with EV charging stations.

Newmark Executive Managing Director John Hundley and Managing Director Jon Engle represented Invivoscribe.

San Diego’s rising office vacancy rate

San Diego’s office vacancy rate at the end of August clocked in at 22.6 percent, rising 350 basis points year-over-year, according to a Yardi Matrix office report. This figure was also considerably higher than the 18.7 percent national threshold.

Despite this rise in available office space, there is still demand for lab space in the metro. Alexandria Real Estate Equities signed a 466,598-square-foot agreement with a multinational pharmaceutical tenant for a build-to-suit research hub. The 16-year lease is the largest life science commitment in the company’s history.

Earlier this year, IQHQ Inc. also signed a 50,000-square-foot lease at its Research and Development District in downtown San Diego. A genomics research laboratory will relocate its West Coast offices at the $1.5 billion property.